FAQ - Important CoQ10-Coenzyme Q10 Information
1. What is Co Enzyme q10?
Coenzyme Q10 (also known as Co Q10, CoQ10 vitamin supplement, ubiquinone, or ubidecarenone, is a compound that is made naturally in the body. A CO Q10 enzyme is a substance needed for the proper functioning of an enzyme, a protein that speeds up the rate at which chemical reactions take place in the body. The Q and the 10 in coenzyme Q10 refer to parts of the compound�s chemical structure.
Coenzyme Q10 is used by cells to produce energy needed for cell growth and maintenance. CO Q10 is also used by the body as an antioxidant. An antioxidant is a substance that protects cells from chemicals called free radicals. Free radicals are highly reactive chemicals that can damage important parts of cells, including deoxyribonucleic acid (DNA). (DNA is a molecule inside cells that carries genetic information and passes it from one generation to the next.) This damage may play a role in the development of cancer.
CoQ10 is found in most body tissues. The highest amounts are found in the heart, liver, kidneys, and pancreas. The lowest amounts are found in the lungs. Tissue levels of coenzyme Q10 decrease as people get older.
WHAT ARE THE BENEFITS OF COMBINING COQ10 AND L-CARNITINE Supplements?... CoQ10 + L-CARNITINE SYRNERGY SUPPLEMENT
Supplement Dosage Directions for use:
Take one or two CoQ10 + L-CARNITINE capsules daily with a meal. Best absorbed if the meal that contains good fats. Well absorbed if taken with an oil such as cod liver oil or flaxseed oil.
Proper dosage for Coenzyme Q10 is usually taken by mouth as a pill.
Have any preclinical (laboratory and animal) studies been conducted
Animal studies have found that coenzyme Q10 stimulated the immune system and increased resistance to disease. Coq10 helped to protect the hearts of animals given the anticancer drug doxorubicin, which can cause damage to the heart muscle. Pet health dog cats taking coq10...
7. Have any side effects or risks been reported?
No serious side effects have been reported from the use of coenzyme Q10. Some patients using CoQ10 have experienced mild insomnia, elevated levels of liver enzymes, rashes, nausea, and upper abdominal pain. Other reported side effects have included dizziness, visual sensitivity to light, irritability, headache, heartburn, and fatigue.
Patients should talk with their health care provider about possible interactions between coenzyme Q10 and prescription drugs they may be taking. Certain drugs, such as those that are used to lower cholesterol or blood sugar levels, may reduce the effects of CoQ10. Coenzyme Q10 may also alter the body�s response to warfarin (a drug that prevents the blood from clotting) and insulin.
Are there any other potential drawbacks?
Coenzyme Q10 is used by the body as an antioxidant. Antioxidants protect cells from free radicals, which are highly reactive chemicals that can damage cells. Some conventional cancer therapies, such as anticancer drugs and radiation treatment, kill cancer cells in part by causing free radicals to form. Researchers are studying whether using coenzyme Q10 along with conventional therapies is positive (i.e., does not interfere with the effects of the conventional therapies, or increases the therapies beneficial effects on cancer cells while protecting normal cells) or negative (i.e., interferes with the therapeutic effects).
Study Suggests Coenzyme Q10 Slows Functional Decline in Parkinson's Disease
Results of the first placebo-controlled, multicenter clinical trial of the compound CoQ10 suggest that it may slow disease progression in patients with early-stage parkinson's disease. While the results must be confirmed in a larger study, they provide hope that this compound may ultimately provide a new way of treating Parkinson's Disease. The phase II study, led by Clifford Shults, M.D., of the University of California, San Diego (UCSD) School of Medicine, looked at a total of 80 PD patients at 10 centers across the country to determine if coenzyme Q10 is safe and if it can slow the rate of functional decline. The study was funded by the National Institute of Neurological Disorders and Stroke and appears in the October 15, 2002, issue of the Archives of Neurology1. "This trial suggested that coenzyme Q10 can slow the rate of deterioration in Parkinson's disease," says Dr. Shults. "However, before the compound is used widely, the results need to be confirmed in a larger group of patients."
Parkinson's Disease is a chronic, progressive neurological disease that affects about 500,000 people in the United States. It results from the loss of brain cells that produce the neurotransmitter dopamine and causes tremor, stiffness of the limbs and trunk, impaired balance and coordination, and slowing of movements. Patients also sometimes develop other symptoms, including difficulty swallowing, disturbed sleep, and emotional problems. PD usually affects people over the age of 50, but it can affect younger people as well. While levodopa and other drugs can ease the symptoms of PD, none of the current treatments has been shown to slow the course of the disease.
The groups that received CoQ10 also had significant increases in the level of coenzyme Q10 in their blood and a significant increase in energy-producing reactions within their mitochondria.
The results of this study suggest that doses of coenzyme Q10 as high as 1,200 mg/day are safe and may be more effective than lower doses, says Dr. Shults. The findings are consistent with those of a recently published study of patients with early Huntington's disease � another degenerative neurological disorder that showed slightly less functional decline in groups that received 600 mg/day of coenzyme Q10.
Other Health Benefits
Migraine Prevention Research
A recent three month open label trial of some 30 subjects with a history of episodic migraine headaches, resulted in the conclusion that Coenzyme Q10 - CoQ10 appeared to be a good for migraine prevention. Of the patients who completed the study, over 60% of the patients had more than 50% reduction in the number of days with migraine headaches.
In this migraine headache test, all participants knew that they were taking Coenzyme CoQ10. There were no adverse side-effects with the use of coenzyme Q10.
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