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Grape Seed Antioxidant Dietary Vitamin Supplements

Grape Seed Health Nutrition Benefits Evidence

Scientists have studied grape seed for the following health problems:

Studies have found grape seed to be one of the best antioxidant, which may help prevent or relieve symptoms of certain conditions, such as vision problems associated with diabetes and wound healing. The safety of long-term use of grape seed is unknown, and more studies are needed to provide definitive answers.

Cardiovascular Heart Health

Studies suggest grape seed may help improve blood circulation, prevent atherosclerosis (clogging of the arteries), lower blood pressure and improve blood cholesterol levels. Some research shows that consumption of grape seed and grape skin in combination, such as in red wine, grape juice or a commercially available vitamin supplement products, may be more beneficial than grape seed alone. Further research is needed.

Retinopathy and High Blood Pressure

Several small studies suggest that grape seed may slow the progression of retinopathy (damage to the retina caused by diabetes or high blood pressure). Further research is needed in this area.

Swelling after surgery or after an injury

Some studies suggest that taking grape seed may decrease swelling that occurs after surgery or after an injury. Further research is needed in this area.

Sun Exposure protection

A small study of healthy female volunteers suggests that Seresis, a pill containing grape seed extract in combination with other ingredients, may help to reduce the severity of a sunburn. Seresis contains carotenoids (beta-carotene and lycopene), vitamins C and E, selenium and proanthocyanidines, the proposed active ingredient in grape seed extract. Further research is needed to confirm these results.

Other Antioxidant Scientic Studies and Research

Grape seed has been studied for the treatment of pancreatitis, cancer, varicose veins, attention deficit hyperactivity disorder and premenstrual syndrome. There is some evidence that a commercial form of grape seed called Activin may help reduce the inflammatory response in patients with systemic sclerosis. There are no clear answers in these areas, and more research is needed.

Unproven but Reported Uses

Grape seed has been suggested for many other uses, based on tradition or on scientific theories. However, these uses have not been thoroughly studied in humans, and there is limited scientific evidence about safety or effectiveness. Some of these suggested uses are for conditions that are potentially serious and even life-threatening. You should consult a health care provider before using grape seed for any unproven use.

Alzheimer's disease
Chronic fatigue syndrome
Connective tissue disorders
Corneal ulcers
Degenerative diseases of the eye
Dental cavities
Diabetic neuropathy
Enzyme function
Excessive weight loss
Eye infection
Eye irritation
Genetic mutations
Hay fever Hemorrhoids
Immune system boosting
Impaired night vision
Improved insulin sensitivity
Increased urination
Intestinal dysfunction
Kidney protection
Liver cirrhosis
Liver protection
Macular degeneration
Menstrual cramps
Parkinson's disease
Protection against toxins (such as chemotherapeutic agents)
Respiratory tract infection prevention
Seasonal allergies
Skin care aging
Skin irritation
Sore throat
Stomach and intestinal ulcers
Telangiectasia (broken capillaries showing on the skin)

Potential Grape Seed Dangers and Side Effects


Individuals allergic to grapes should not take grape seed. There are at least two published cases of allergic reaction to the active compounds found in grape seed.

Side Effects

Many experts consider grape seed to be safe, with few reports of side effects. The most common complaints include dry, itchy scalp; headache; dizziness and nausea. In theory, grape seed may increase the risk of bleeding. You may need to stop taking grape seed before some surgeries; discuss this with your health care provider.

Pregnancy And Breast-Feeding

Grape seed use during pregnancy and breast-feeding has not been studied and cannot be recommended.


Interactions with drugs, supplements and other herbs have not been thoroughly studied. The interactions listed below have been reported in scientific publications. If you are taking prescription drugs, speak with your health care provider or pharmacist before using herbs or dietary supplements.

Interactions With Drugs

In theory, grape seed may increase the risk of bleeding when used with anticoagulants (blood thinners) or antiplatelet drugs. Examples include warfarin (Coumadin), heparin and clopidogrel (Plavix). Some pain relievers may also increase the risk of bleeding if used with grape seed. Examples include aspirin, ibuprofen (Motrin, Advil) and naproxen (Naprosyn, Aleve, Anaprox). Grape seed may interact with prescription drugs, such as angiotensin-converting enzyme inhibitors, methotrexate, allopurinol and cholesterol-lowering drugs. There is evidence that grape seed may interfere with the way the liver breaks down certain drugs. As a result, grape seed may cause the levels of drugs in the body to be too high, leading to serious side effects. If you are taking prescription drugs, ask your health care provider for advice before you take grape seed.

Interactions With Herbs And Dietary Supplements In theory, grape seed may increase the risk of bleeding when also taken with other products that are believed to increase the risk of bleeding. Examples include Ginkgo biloba and garlic (Allium sativum). In theory, grape seed may excessively lower cholesterol levels in the blood if also taken with herbs and supplements that lower cholesterol levels, such as red yeast. Grape seed may also increase the blood levels of herbs processed by the liver, such as chasteberry (Vitex agnus-castus). There is some evidence that grape seed may enhance the effectiveness of vitamin C and vitamin E.

Grape Seed Vitamin Supplement Dosage

The doses listed below are based on scientific research, publications or traditional use. Because most herbs and supplements have not been thoroughly studied or monitored, safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients even within the same brand. Combination products often contain small amounts of each ingredient and may not be effective. Grape seed extract may be standardized to contain 40 percent to 80 percent proanthocyanidins or 95 percent polyphenols per dose.


Although grape seed has been suggested for many conditions, the best evidence supports its use for its antioxidant effects, for improving cardiovascular heart health, for retinopathy (damage to the retina caused by diabetes or high blood pressure) and for swelling that occurs after surgery or after an injury. Further research is needed in these areas before a strong recommendation can be made. Grape seed has not been proven for any other use. Pregnant or breast-feeding women should avoid grape seed. People actively bleeding, those with blood disorders and those taking blood thinners should also avoid grape seed. If you are taking prescription drugs or over-the-counter pain relievers, consult your pharmacist or health care provider before taking grape seed. Consult your health care provider immediately if you experience side effects.

Suggested Grape Seed Antioxidant Supplement Source; Dr Koch's Vitacel GH-8 Plus Grape Seed + Milk Thistle + Ginkgo + Artichoke extracts formula.

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